sudo apt install amule amule-daemon amule-utils amule-utils-gui amule-gnome-support
sudo systemctl stop amule-daemon
sudo systemctl disable amule-daemon
sudo  nano /etc/default/amule-daemon

(Cambiamos la siguiente línea)
AMULED_USER="tu_usuario"
(Guardamos y salimos)

sudo systemctl start amule-daemon
sudo systemctl stop amule-daemon
echo -n tu_nick_de_amule | md5sum
(Copiar el hash que devuelve para pegarlo en su lugar correspondiente del archivo amule.conf)
nano /home/tu_usuario/.aMule/amule.conf

[eMule]
AppVersion=2.3.3
<color yellow>Nick=tu_nick_de_amule</color>
QueueSizePref=50
MaxUpload=1536
MaxDownload=0
SlotAllocation=50
Port=44662
UDPPort=44672
UDPEnable=1
Address=
Autoconnect=1
MaxSourcesPerFile=600
MaxConnections=1000
MaxConnectionsPerFiveSeconds=100
RemoveDeadServer=1
DeadServerRetry=3
ServerKeepAliveTimeout=0
Reconnect=1
Scoresystem=1
Serverlist=1
AddServerListFromServer=0
AddServerListFromClient=0
SafeServerConnect=0
AutoConnectStaticOnly=0
UPnPEnabled=0
UPnPTCPPort=50000
SmartIdCheck=1
ConnectToKad=1
ConnectToED2K=1
TempDir=/home/tu_usuario/.aMule/Temp
IncomingDir=/home/tu_usuario/.aMule/Incoming
ICH=1
AICHTrust=0
CheckDiskspace=1
MinFreeDiskSpace=1
AddNewFilesPaused=0
PreviewPrio=0
ManualHighPrio=0
StartNextFile=0
StartNextFileSameCat=0
StartNextFileAlpha=0
FileBufferSizePref=70
DAPPref=1
UAPPref=1
AllocateFullFile=1
OSDirectory=/home/tu_usuario//.aMule/
OnlineSignature=0
OnlineSignatureUpdate=5
EnableTrayIcon=0
MinToTray=0
Notifications=0
ConfirmExit=1
StartupMinimized=0
3DDepth=5
ToolTipDelay=1
ShowOverhead=0
ShowInfoOnCatTabs=1
VerticalToolbar=0
GeoIPEnabled=0
ShowVersionOnTitle=0
VideoPlayer=
StatGraphsInterval=3
statsInterval=30
DownloadCapacity=300
UploadCapacity=100
StatsAverageMinutes=5
VariousStatisticsMaxValue=100
SeeShare=2
FilterLanIPs=1
ParanoidFiltering=1
IPFilterAutoLoad=1
IPFilterURL=http://upd.emule-security.org/ipfilter.zip
FilterLevel=127
IPFilterSystem=0
FilterMessages=1
FilterAllMessages=0
MessagesFromFriendsOnly=0
MessageFromValidSourcesOnly=1
FilterWordMessages=0
MessageFilter=
ShowMessagesInLog=1
FilterComments=0
CommentFilter=
ShareHiddenFiles=1
AutoSortDownloads=0
NewVersionCheck=0
AdvancedSpamFilter=1
MessageUseCaptchas=1
Language=
SplitterbarPosition=75
YourHostname=
DateTimeFormat=%A, %x, %X
AllcatType=0
ShowAllNotCats=0
SmartIdState=1
DropSlowSources=0
KadNodesUrl=http://upd.emule-security.org/nodes.dat
Ed2kServersUrl=http://upd.emule-security.org/server.met
ShowRatesOnTitle=0
GeoLiteCountryUpdateUrl=http://geolite.maxmind.com/download/geoip/database/GeoLiteCountry/GeoIP.dat.gz
StatsServerName=Shorty's ED2K stats
StatsServerURL=http://ed2k.shortypower.dyndns.org/?hash=
CreateSparseFiles=1
StatColor0=4194304
StatColor1=16761024
StatColor2=8454016
StatColor3=53760
StatColor4=32768
StatColor5=8421631
StatColor6=200
StatColor7=140
StatColor8=16750230
StatColor9=12583104
StatColor10=8454143
StatColor11=0
StatColor12=8454016
StatColor13=53760
StatColor14=32768
TableOrderingServer=N:0:0
TableWidthsServer=N:150,A:140,P:25,D:150,p:25,U:40,F:45,r:60,f:40,S:40,V:80
TableOrderingDownload=a:0:0
TableWidthsDownload=a:30,N:260,Z:60,T:65,C:65,S:65,P:170,u:50,p:55,s:70,r:110,c:220,R:220
TableOrderingSources=N:0:0
TableWidthsSources=N:260,D:65,S:65,U:65,P:170,V:50,q:55,O:110,F:200,R:200,m:100
TableOrderingShared=N:0:0
TableWidthsShared=N:250,Z:100,Y:50,p:70,I:220,Q:100,A:100,T:120,R:100,P:120,C:120,D:220
TableOrderingPeers=N:0:0
TableWidthsPeers=N:260,D:65,S:65,U:65,s:65,A:170,V:50,Q:70,q:70,O:110,f:200,m:100
[Browser]
OpenPageInTab=1
CustomBrowserString=
[Proxy]
ProxyEnableProxy=0
ProxyType=0
ProxyName=
ProxyPort=1080
ProxyEnablePassword=0
ProxyUser=
ProxyPassword=
[ExternalConnect]
UseSrcSeeds=0
AcceptExternalConnections=1
ECAddress=
ECPort=4712
ECPassword=(Pegar aquí el hash obtenido antes sin los paréntesis)
UPnPECEnabled=0
ShowProgressBar=1
ShowPercent=1
UseSecIdent=1
IpFilterClients=1
IpFilterServers=1
TransmitOnlyUploadingClients=0
[WebServer]
Enabled=1
Password=(Pegar aquí el hash obtenido antes sin los paréntesis)
PasswordLow=
Port=44711
WebUPnPTCPPort=50001
UPnPWebServerEnabled=0
UseGzip=1
UseLowRightsUser=0
PageRefreshTime=120
Template=default
Path=amuleweb
[GUI]
HideOnClose=0
[GUI/TransferWnd]
Splitter=386
ShowClientList=1
[Razor_Preferences]
FastED2KLinksHandler=1
MAIN_X_POS=42
MAIN_Y_POS=-1
MAIN_X_SIZE=1877
MAIN_Y_SIZE=1080
Maximized=1
SRV_SPLITTER_POS=463
[SkinGUIOptions]
Skin=
[Statistics]
MaxClientVersions=0
[Obfuscation]
IsClientCryptLayerSupported=1
IsCryptLayerRequested=1
IsClientCryptLayerRequired=0
CryptoPaddingLenght=254
CryptoKadUDPKey=911052936
[PowerManagement]
PreventSleepWhileDownloading=0
[UserEvents]
[UserEvents/DownloadCompleted]
CoreEnabled=0
CoreCommand=
GUIEnabled=0
GUICommand=
[UserEvents/NewChatSession]
CoreEnabled=0
CoreCommand=
GUIEnabled=0
GUICommand=
[UserEvents/OutOfDiskSpace]
CoreEnabled=0
CoreCommand=
GUIEnabled=0
GUICommand=
[UserEvents/ErrorOnCompletion]
CoreEnabled=0
CoreCommand=
GUIEnabled=0
GUICommand=
[HTTPDownload]
URL_1=http://upd.emule-security.org/ipfilter.zip
URL_2=http://upd.emule-security.org/server.met
URL_5=http://upd.emule-security.org/nodes.dat
URL_3=http://upd.emule-security.org/server.met

(Guardamos y salimos)

sudo nano /etc/systemd/system/amuled.service

[Unit]
Description=Amuled P2P File Sharing Daemon
After=network.target

[Service]
Type=simple
User=tu_usuario
WorkingDirectory=/home/tu_usuario/.aMule
ExecStart=/usr/bin/amuled
Restart=always

[Install]
WantedBy=multi-user.target

(Guardamos y salismo)

sudo systemctl daemon-reload
sudo systemctl status amuled.service
sudo systemctl enable amuled.service
sudo systemctl start amuled.service
sudo systemctl status amuled.service

Luego, abrir con amulegui

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